273351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1572966..1574661 Replicon chromosome
Accession NZ_CP118638
Organism Pseudomonas aeruginosa strain P9

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PUN20_RS07300 Protein ID WP_003112901.1
Coordinates 1572966..1573835 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PUN20_RS07305 Protein ID WP_003112902.1
Coordinates 1573828..1574661 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUN20_RS07275 (PUN20_07275) 1568974..1569825 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PUN20_RS07280 (PUN20_07280) 1569866..1570873 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
PUN20_RS07285 (PUN20_07285) 1570870..1571646 + 777 WP_003112898.1 ABC transporter permease -
PUN20_RS07290 (PUN20_07290) 1571652..1572413 + 762 WP_088412903.1 SDR family oxidoreductase -
PUN20_RS07295 (PUN20_07295) 1572427..1572957 + 531 WP_003112900.1 cupin domain-containing protein -
PUN20_RS07300 (PUN20_07300) 1572966..1573835 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PUN20_RS07305 (PUN20_07305) 1573828..1574661 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PUN20_RS07310 (PUN20_07310) 1574648..1575445 + 798 WP_017001845.1 SDR family oxidoreductase -
PUN20_RS07315 (PUN20_07315) 1575438..1577120 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PUN20_RS07320 (PUN20_07320) 1577131..1577934 + 804 WP_003130116.1 aspartate dehydrogenase -
PUN20_RS07325 (PUN20_07325) 1577946..1579430 + 1485 WP_023102925.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T273351 WP_003112901.1 NZ_CP118638:1572966-1573835 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT273351 WP_003112902.1 NZ_CP118638:1573828-1574661 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References