Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142941..143446 Replicon chromosome
Accession NZ_CP118638
Organism Pseudomonas aeruginosa strain P9

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PUN20_RS00665 Protein ID WP_003083773.1
Coordinates 142941..143222 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PUN20_RS00670 Protein ID WP_003083775.1
Coordinates 143219..143446 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUN20_RS00640 (PUN20_00640) 138192..139541 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PUN20_RS00645 (PUN20_00645) 139590..140276 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PUN20_RS00650 (PUN20_00650) 140377..141111 + 735 WP_003117208.1 GntR family transcriptional regulator -
PUN20_RS00655 (PUN20_00655) 141291..141701 + 411 WP_003101225.1 aegerolysin family protein -
PUN20_RS00660 (PUN20_00660) 141733..142641 - 909 WP_016561475.1 LysR family transcriptional regulator -
PUN20_RS00665 (PUN20_00665) 142941..143222 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PUN20_RS00670 (PUN20_00670) 143219..143446 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PUN20_RS00675 (PUN20_00675) 143623..144243 - 621 WP_009314940.1 hypothetical protein -
PUN20_RS00680 (PUN20_00680) 144344..144844 + 501 WP_003112629.1 LEA type 2 family protein -
PUN20_RS00685 (PUN20_00685) 144917..145258 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PUN20_RS00690 (PUN20_00690) 145340..146767 - 1428 WP_003083784.1 GABA permease -
PUN20_RS00695 (PUN20_00695) 146936..148429 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T273350 WP_003083773.1 NZ_CP118638:c143222-142941 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT273350 WP_003083775.1 NZ_CP118638:c143446-143219 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References