Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4226347..4226863 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name relE Uniprot ID A0A5U7R3Q6
Locus tag PWO88_RS20660 Protein ID WP_023243277.1
Coordinates 4226347..4226631 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PWO88_RS20665 Protein ID WP_000212724.1
Coordinates 4226621..4226863 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS20645 (4221463) 4221463..4223115 + 1653 WP_023243275.1 alpha,alpha-phosphotrehalase -
PWO88_RS20650 (4223524) 4223524..4225662 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PWO88_RS20655 (4225879) 4225879..4226343 + 465 WP_023243276.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PWO88_RS20660 (4226347) 4226347..4226631 - 285 WP_023243277.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWO88_RS20665 (4226621) 4226621..4226863 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PWO88_RS20670 (4226941) 4226941..4228854 - 1914 WP_001212131.1 BglG family transcription antiterminator -
PWO88_RS20675 (4228871) 4228871..4229611 - 741 WP_023243278.1 KDGP aldolase family protein -
PWO88_RS20680 (4229608) 4229608..4230726 - 1119 WP_023243279.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PWO88_RS20685 (4230710) 4230710..4231843 - 1134 WP_023243280.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10801.62 Da        Isoelectric Point: 9.6730

>T273346 WP_023243277.1 NZ_CP118633:c4226631-4226347 [Salmonella enterica subsp. enterica serovar Anatum]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT273346 WP_000212724.1 NZ_CP118633:c4226863-4226621 [Salmonella enterica subsp. enterica serovar Anatum]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U7R3Q6

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References