Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4139593..4140169 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PWO88_RS20250 Protein ID WP_001131963.1
Coordinates 4139882..4140169 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag PWO88_RS20245 Protein ID WP_000063143.1
Coordinates 4139593..4139895 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS20230 (4136103) 4136103..4138253 + 2151 WP_023244016.1 pyruvate/proton symporter BtsT -
PWO88_RS20235 (4138348) 4138348..4138551 + 204 WP_000460616.1 YbdD/YjiX family protein -
PWO88_RS20240 (4138562) 4138562..4139518 + 957 WP_000612222.1 GTPase -
PWO88_RS20245 (4139593) 4139593..4139895 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
PWO88_RS20250 (4139882) 4139882..4140169 - 288 WP_001131963.1 BrnT family toxin Toxin
PWO88_RS20255 (4140438) 4140438..4141352 - 915 WP_023244015.1 restriction endonuclease -
PWO88_RS20260 (4141550) 4141550..4145059 + 3510 WP_023244014.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T273345 WP_001131963.1 NZ_CP118633:c4140169-4139882 [Salmonella enterica subsp. enterica serovar Anatum]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT273345 WP_000063143.1 NZ_CP118633:c4139895-4139593 [Salmonella enterica subsp. enterica serovar Anatum]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References