Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3537512..3538132 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PWO88_RS17480 Protein ID WP_001280991.1
Coordinates 3537914..3538132 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PWO88_RS17475 Protein ID WP_000344807.1
Coordinates 3537512..3537886 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS17465 (3532651) 3532651..3533844 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PWO88_RS17470 (3533867) 3533867..3537016 + 3150 WP_080155288.1 efflux RND transporter permease AcrB -
PWO88_RS17475 (3537512) 3537512..3537886 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PWO88_RS17480 (3537914) 3537914..3538132 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PWO88_RS17485 (3538311) 3538311..3538862 + 552 WP_080155289.1 maltose O-acetyltransferase -
PWO88_RS17490 (3538978) 3538978..3539448 + 471 WP_000136183.1 YlaC family protein -
PWO88_RS17495 (3539504) 3539504..3539644 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PWO88_RS17500 (3539650) 3539650..3539910 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PWO88_RS17505 (3540135) 3540135..3541685 + 1551 WP_023243162.1 EAL domain-containing protein -
PWO88_RS17515 (3541916) 3541916..3542305 + 390 WP_000961285.1 MGMT family protein -
PWO88_RS17520 (3542338) 3542338..3542907 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T273342 WP_001280991.1 NZ_CP118633:3537914-3538132 [Salmonella enterica subsp. enterica serovar Anatum]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT273342 WP_000344807.1 NZ_CP118633:3537512-3537886 [Salmonella enterica subsp. enterica serovar Anatum]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References