273341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2470373..2470895 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name stbE Uniprot ID A0A5U0LRG3
Locus tag PWO88_RS12125 Protein ID WP_023243932.1
Coordinates 2470611..2470895 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PWO88_RS12120 Protein ID WP_000885424.1
Coordinates 2470373..2470621 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS12090 (2466487) 2466487..2467043 + 557 Protein_2368 hypothetical protein -
PWO88_RS12095 (2467321) 2467321..2467602 + 282 WP_001580000.1 hypothetical protein -
PWO88_RS12100 (2467973) 2467973..2468569 + 597 Protein_2370 helix-turn-helix domain-containing protein -
PWO88_RS12105 (2468625) 2468625..2469533 - 909 WP_077909464.1 hypothetical protein -
PWO88_RS12110 (2469684) 2469684..2470016 - 333 WP_023244369.1 DUF1493 family protein -
PWO88_RS12115 (2470006) 2470006..2470221 - 216 WP_000206207.1 hypothetical protein -
PWO88_RS12120 (2470373) 2470373..2470621 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PWO88_RS12125 (2470611) 2470611..2470895 + 285 WP_023243932.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWO88_RS12130 (2471066) 2471066..2471451 + 386 Protein_2376 RidA family protein -
PWO88_RS12135 (2471503) 2471503..2472582 - 1080 WP_023244370.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PWO88_RS12140 (2472775) 2472775..2473263 - 489 WP_023243930.1 MarR family winged helix-turn-helix transcriptional regulator -
PWO88_RS12145 (2473308) 2473308..2474816 + 1509 WP_023243929.1 FAD-dependent oxidoreductase -
PWO88_RS12150 (2474806) 2474806..2475782 + 977 Protein_2380 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2467321..2477408 10087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11057.82 Da        Isoelectric Point: 10.6500

>T273341 WP_023243932.1 NZ_CP118633:2470611-2470895 [Salmonella enterica subsp. enterica serovar Anatum]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAIYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT273341 WP_000885424.1 NZ_CP118633:2470373-2470621 [Salmonella enterica subsp. enterica serovar Anatum]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0LRG3

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References