Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2005552..2006142 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name pemK Uniprot ID A0A5Z3IR43
Locus tag PWO88_RS09730 Protein ID WP_023243734.1
Coordinates 2005810..2006142 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A618JW87
Locus tag PWO88_RS09725 Protein ID WP_023243733.1
Coordinates 2005552..2005809 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS09710 (2002214) 2002214..2004169 - 1956 WP_024149369.1 hypothetical protein -
PWO88_RS09715 (2004528) 2004528..2005001 + 474 WP_194548145.1 hypothetical protein -
PWO88_RS09720 (2004998) 2004998..2005204 + 207 WP_023243732.1 helix-turn-helix transcriptional regulator -
PWO88_RS09725 (2005552) 2005552..2005809 + 258 WP_023243733.1 MazE family transcriptional regulator Antitoxin
PWO88_RS09730 (2005810) 2005810..2006142 + 333 WP_023243734.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PWO88_RS09735 (2006977) 2006977..2007861 + 885 WP_031609821.1 integrase domain-containing protein -
PWO88_RS09740 (2008806) 2008806..2010068 - 1263 WP_023244267.1 integrase arm-type DNA-binding domain-containing protein -
PWO88_RS09750 (2010727) 2010727..2011032 - 306 Protein_1909 Arm DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.65 Da        Isoelectric Point: 10.5834

>T273336 WP_023243734.1 NZ_CP118633:2005810-2006142 [Salmonella enterica subsp. enterica serovar Anatum]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVIPVTSGGNFARAAGFTVSLEGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9512.02 Da        Isoelectric Point: 4.4929

>AT273336 WP_023243733.1 NZ_CP118633:2005552-2005809 [Salmonella enterica subsp. enterica serovar Anatum]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMREEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z3IR43

Antitoxin

Source ID Structure
AlphaFold DB A0A618JW87

References