Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1011318..1012132 | Replicon | chromosome |
| Accession | NZ_CP118633 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain 2089b | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A623LUR5 |
| Locus tag | PWO88_RS04840 | Protein ID | WP_023243184.1 |
| Coordinates | 1011318..1011845 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PWO88_RS04845 | Protein ID | WP_000855694.1 |
| Coordinates | 1011842..1012132 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PWO88_RS04810 (1007520) | 1007520..1007918 | + | 399 | Protein_942 | cytoplasmic protein | - |
| PWO88_RS04815 (1008109) | 1008109..1008348 | + | 240 | Protein_943 | hypothetical protein | - |
| PWO88_RS04820 (1008505) | 1008505..1009173 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| PWO88_RS04825 (1009200) | 1009200..1009694 | + | 495 | WP_000424947.1 | hypothetical protein | - |
| PWO88_RS04830 (1009939) | 1009939..1010595 | - | 657 | WP_023243186.1 | protein-serine/threonine phosphatase | - |
| PWO88_RS04835 (1010825) | 1010825..1011245 | + | 421 | Protein_947 | transposase | - |
| PWO88_RS04840 (1011318) | 1011318..1011845 | - | 528 | WP_023243184.1 | GNAT family N-acetyltransferase | Toxin |
| PWO88_RS04845 (1011842) | 1011842..1012132 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PWO88_RS04850 (1012402) | 1012402..1012602 | - | 201 | Protein_950 | IS3 family transposase | - |
| PWO88_RS04855 (1013005) | 1013005..1013448 | - | 444 | WP_000715099.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PWO88_RS04860 (1013906) | 1013906..1014556 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| PWO88_RS04865 (1014553) | 1014553..1016241 | + | 1689 | WP_023244646.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1011051..1012602 | 1551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19121.98 Da Isoelectric Point: 9.0946
>T273335 WP_023243184.1 NZ_CP118633:c1011845-1011318 [Salmonella enterica subsp. enterica serovar Anatum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT273335 WP_000855694.1 NZ_CP118633:c1012132-1011842 [Salmonella enterica subsp. enterica serovar Anatum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A623LUR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |