Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 864675..865300 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PWO88_RS04175 Protein ID WP_000911337.1
Coordinates 864902..865300 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PWO88_RS04170 Protein ID WP_000557549.1
Coordinates 864675..864902 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS04140 (859739) 859739..860837 + 1099 WP_010989230.1 peptide chain release factor 2 -
PWO88_RS04145 (860847) 860847..862364 + 1518 WP_000003339.1 lysine--tRNA ligase -
PWO88_RS04150 (862440) 862440..862985 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PWO88_RS04155 (863250) 863250..864008 + 759 WP_000244328.1 amidase activator ActS -
PWO88_RS04165 (864254) 864254..864466 - 213 WP_024149321.1 endonuclease -
PWO88_RS04170 (864675) 864675..864902 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PWO88_RS04175 (864902) 864902..865300 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PWO88_RS04180 (866106) 866106..866642 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PWO88_RS04185 (866689) 866689..867321 + 633 WP_000835264.1 YfdX family protein -
PWO88_RS04190 (868040) 868040..868621 + 582 WP_023243212.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 864254..874478 10224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T273334 WP_000911337.1 NZ_CP118633:864902-865300 [Salmonella enterica subsp. enterica serovar Anatum]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT273334 WP_000557549.1 NZ_CP118633:864675-864902 [Salmonella enterica subsp. enterica serovar Anatum]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References