Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 211695..212455 | Replicon | chromosome |
| Accession | NZ_CP118633 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain 2089b | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | PWO88_RS00995 | Protein ID | WP_000533909.1 |
| Coordinates | 211970..212455 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | PWO88_RS00990 | Protein ID | WP_000965886.1 |
| Coordinates | 211695..211982 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PWO88_RS00970 (207100) | 207100..208011 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| PWO88_RS00975 (208021) | 208021..210090 | + | 2070 | WP_020437730.1 | glycine--tRNA ligase subunit beta | - |
| PWO88_RS00980 (210480) | 210480..210878 | + | 399 | Protein_194 | IS3 family transposase | - |
| PWO88_RS00985 (211050) | 211050..211517 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| PWO88_RS00990 (211695) | 211695..211982 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| PWO88_RS00995 (211970) | 211970..212455 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| PWO88_RS01000 (212826) | 212826..213365 | - | 540 | WP_000047140.1 | copper-binding periplasmic metallochaperone CueP | - |
| PWO88_RS01005 (213540) | 213540..213752 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| PWO88_RS01010 (214040) | 214040..214330 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| PWO88_RS01015 (214769) | 214769..215479 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| PWO88_RS01020 (215529) | 215529..216503 | - | 975 | WP_000804693.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| PWO88_RS01025 (216722) | 216722..217384 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T273331 WP_000533909.1 NZ_CP118633:211970-212455 [Salmonella enterica subsp. enterica serovar Anatum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT273331 WP_000965886.1 NZ_CP118633:211695-211982 [Salmonella enterica subsp. enterica serovar Anatum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |