Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 211695..212455 Replicon chromosome
Accession NZ_CP118633
Organism Salmonella enterica subsp. enterica serovar Anatum strain 2089b

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PWO88_RS00995 Protein ID WP_000533909.1
Coordinates 211970..212455 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PWO88_RS00990 Protein ID WP_000965886.1
Coordinates 211695..211982 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWO88_RS00970 (207100) 207100..208011 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PWO88_RS00975 (208021) 208021..210090 + 2070 WP_020437730.1 glycine--tRNA ligase subunit beta -
PWO88_RS00980 (210480) 210480..210878 + 399 Protein_194 IS3 family transposase -
PWO88_RS00985 (211050) 211050..211517 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PWO88_RS00990 (211695) 211695..211982 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PWO88_RS00995 (211970) 211970..212455 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PWO88_RS01000 (212826) 212826..213365 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
PWO88_RS01005 (213540) 213540..213752 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PWO88_RS01010 (214040) 214040..214330 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PWO88_RS01015 (214769) 214769..215479 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PWO88_RS01020 (215529) 215529..216503 - 975 WP_000804693.1 glyoxylate/hydroxypyruvate reductase GhrB -
PWO88_RS01025 (216722) 216722..217384 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T273331 WP_000533909.1 NZ_CP118633:211970-212455 [Salmonella enterica subsp. enterica serovar Anatum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT273331 WP_000965886.1 NZ_CP118633:211695-211982 [Salmonella enterica subsp. enterica serovar Anatum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References