Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 524320..525022 Replicon plasmid pVWJL.P1
Accession NZ_CP118630
Organism Pantoea dispersa strain VWJL.P1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PWF83_RS21820 Protein ID WP_264444068.1
Coordinates 524639..525022 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A246NDH1
Locus tag PWF83_RS21815 Protein ID WP_058770279.1
Coordinates 524320..524646 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWF83_RS21795 (PWF83_21805) 519947..520981 - 1035 WP_275029419.1 aldehyde reductase -
PWF83_RS21800 (PWF83_21810) 521090..522022 + 933 WP_275029421.1 AraC family transcriptional regulator -
PWF83_RS21805 (PWF83_21815) 522051..523085 - 1035 WP_275029423.1 L-glyceraldehyde 3-phosphate reductase -
PWF83_RS21810 (PWF83_21820) 523255..524154 + 900 WP_275029425.1 LysR family transcriptional regulator -
PWF83_RS21815 (PWF83_21825) 524320..524646 - 327 WP_058770279.1 helix-turn-helix domain-containing protein Antitoxin
PWF83_RS21820 (PWF83_21830) 524639..525022 - 384 WP_264444068.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWF83_RS21825 (PWF83_21835) 525328..525618 + 291 WP_058770280.1 hypothetical protein -
PWF83_RS21830 (PWF83_21840) 525643..527070 - 1428 WP_275029429.1 trehalose-6-phosphate synthase -
PWF83_RS21835 (PWF83_21845) 527242..528105 - 864 WP_275029432.1 substrate-binding domain-containing protein -
PWF83_RS21840 (PWF83_21850) 528340..529035 + 696 WP_058775966.1 hypothetical protein -
PWF83_RS21845 (PWF83_21855) 529134..529664 + 531 WP_021508986.1 outer membrane lipoprotein Blc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..708540 708540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-123)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14083.43 Da        Isoelectric Point: 10.2744

>T273327 WP_264444068.1 NZ_CP118630:c525022-524639 [Pantoea dispersa]
MAIYVLKPFDRNFKGDMIADIKLCLAARELIAGQYEASLGGGVYKKRIPLGAGKSGGARAIVAFKSQKHLFFVNGYAKST
TKSGIREIKEDEINFYRQVASQLFAMTTEQERAAIKARKMREVICDG

Download         Length: 384 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12292.30 Da        Isoelectric Point: 7.3214

>AT273327 WP_058770279.1 NZ_CP118630:c524646-524320 [Pantoea dispersa]
MVDHLKDLQEIAHDFNPLGVISDELTEKIDSRVRLRELRTSLPVLQLMSGEAIRELRERHGLSQAMLAAYIGLSPATVVK
WEREEKKPNGAALRLLNLIDRKGLEVLR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NDH1

References