Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 594089..594759 Replicon plasmid pCTYH.Ch1_2
Accession NZ_CP118612
Organism Ensifer adhaerens strain CTYH.Ch1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PWG15_RS35740 Protein ID WP_275027612.1
Coordinates 594089..594508 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PWG15_RS35745 Protein ID WP_275027613.1
Coordinates 594505..594759 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWG15_RS35725 (PWG15_35720) 589300..592365 + 3066 WP_275027609.1 GAF domain-containing protein -
PWG15_RS35730 (PWG15_35725) 592362..592751 + 390 WP_275027611.1 response regulator -
PWG15_RS35735 (PWG15_35730) 592748..594007 + 1260 WP_275028014.1 adenylate/guanylate cyclase domain-containing protein -
PWG15_RS35740 (PWG15_35735) 594089..594508 - 420 WP_275027612.1 type II toxin-antitoxin system VapC family toxin Toxin
PWG15_RS35745 (PWG15_35740) 594505..594759 - 255 WP_275027613.1 plasmid stabilization protein Antitoxin
PWG15_RS35750 (PWG15_35745) 595568..596053 + 486 WP_275027614.1 adenosine-specific kinase -
PWG15_RS35755 (PWG15_35750) 596404..596703 + 300 WP_275027615.1 HigA family addiction module antitoxin -
PWG15_RS35760 (PWG15_35755) 596921..597154 + 234 WP_275027616.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
PWG15_RS35765 (PWG15_35760) 597151..597561 + 411 Protein_601 type II toxin-antitoxin system VapC family toxin -
PWG15_RS35770 (PWG15_35765) 597763..599289 - 1527 WP_275027618.1 HlyD family type I secretion periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..623840 623840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14765.95 Da        Isoelectric Point: 4.8311

>T273306 WP_275027612.1 NZ_CP118612:c594508-594089 [Ensifer adhaerens]
MIVLDTNVVSEAMKPAPDLAVRTWLNDQVAETLYLSSVTLAELLFGIAALPEGRRKKALAETLDGLLALFDDRVLPFDTA
AARHYADLAATARAAGKGFPTPDGYIAAIVASKGFTIATRDTSPFEAAGVPVVNPWTHL

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9548.87 Da        Isoelectric Point: 5.7485

>AT273306 WP_275027613.1 NZ_CP118612:c594759-594505 [Ensifer adhaerens]
MAILTVRNVPDEVHRALRVRAAIHGRSTEAEVREILERAVKPEQRVRIGDALAELSGRLGLTNEDFEVFDQVRDKAPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References