Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 682083..682873 Replicon plasmid pCTYH.Ch1_1
Accession NZ_CP118611
Organism Ensifer adhaerens strain CTYH.Ch1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PWG15_RS23505 Protein ID WP_275026442.1
Coordinates 682376..682873 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0T7A4X6
Locus tag PWG15_RS23500 Protein ID WP_058321439.1
Coordinates 682083..682379 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWG15_RS23475 (PWG15_23470) 677496..678047 + 552 WP_275026437.1 MaoC family dehydratase -
PWG15_RS23480 (PWG15_23475) 678055..679215 + 1161 WP_275026438.1 CaiB/BaiF CoA-transferase family protein -
PWG15_RS23485 (PWG15_23480) 679212..680348 + 1137 WP_275026439.1 extracellular solute-binding protein -
PWG15_RS23490 (PWG15_23485) 680519..681445 + 927 WP_275027184.1 nucleotidyltransferase and HEPN domain-containing protein -
PWG15_RS23495 (PWG15_23490) 681723..681893 - 171 WP_275026440.1 ATP-binding cassette domain-containing protein -
PWG15_RS23500 (PWG15_23495) 682083..682379 + 297 WP_058321439.1 DUF1778 domain-containing protein Antitoxin
PWG15_RS23505 (PWG15_23500) 682376..682873 + 498 WP_275026442.1 GNAT family N-acetyltransferase Toxin
PWG15_RS23510 (PWG15_23505) 683213..683371 - 159 WP_275026444.1 hypothetical protein -
PWG15_RS23515 (PWG15_23510) 683462..684298 - 837 WP_275026446.1 amidohydrolase -
PWG15_RS23520 (PWG15_23515) 684375..685163 - 789 WP_275026448.1 IclR family transcriptional regulator -
PWG15_RS23525 (PWG15_23520) 685328..686647 + 1320 WP_275027186.1 extracellular solute-binding protein -
PWG15_RS23530 (PWG15_23525) 686729..687625 + 897 WP_275026450.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - wcbK / katA 1..2779603 2779603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-142)

Antitoxin

Vibrio phage ICP1, Orf50

(8-97)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17823.45 Da        Isoelectric Point: 8.0520

>T273303 WP_275026442.1 NZ_CP118611:682376-682873 [Ensifer adhaerens]
VSLNAPTPLADQHELADFNSGVPELDDWLRRRARTNQIGGASRTFVVCEGNRVIAYYALASGAVKQPEAPGRFRRNMPDP
IPVAVLGRLAIDGAYQGRGIGRALVRDAGFRLLNAAEILGIRGVLVHAISEDARAFYEAVGFLPSPSDPMMLMVGLHDLK
SALNF

Download         Length: 498 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.52 Da        Isoelectric Point: 6.3714

>AT273303 WP_058321439.1 NZ_CP118611:682083-682379 [Ensifer adhaerens]
MATSNTSKSPDASVPLNMRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRSVFTVSPEIYAEYLARLDAPAQ
TNERLKRTMSTKAPWDEA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7A4X6

References