Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-higA/HigB-HigA |
| Location | 5532407..5533287 | Replicon | chromosome |
| Accession | NZ_CP118607 | ||
| Organism | Pseudomonas sp. PSKL.D1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | PVV54_RS24865 | Protein ID | WP_274907727.1 |
| Coordinates | 5532934..5533287 (-) | Length | 118 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | PVV54_RS24860 | Protein ID | WP_274907726.1 |
| Coordinates | 5532407..5532880 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVV54_RS24825 (PVV54_24825) | 5527832..5528521 | + | 690 | WP_274907720.1 | ABC transporter permease | - |
| PVV54_RS24830 (PVV54_24830) | 5528631..5529836 | + | 1206 | WP_274907721.1 | methyltransferase | - |
| PVV54_RS24835 (PVV54_24835) | 5530193..5530456 | - | 264 | WP_274907722.1 | DUF3077 domain-containing protein | - |
| PVV54_RS24840 (PVV54_24840) | 5530449..5530718 | - | 270 | WP_274907723.1 | hypothetical protein | - |
| PVV54_RS24845 (PVV54_24845) | 5531127..5531375 | + | 249 | WP_274907724.1 | hypothetical protein | - |
| PVV54_RS24855 (PVV54_24855) | 5531679..5532002 | + | 324 | WP_274907725.1 | helix-turn-helix transcriptional regulator | - |
| PVV54_RS24860 (PVV54_24860) | 5532407..5532880 | - | 474 | WP_274907726.1 | transcriptional regulator | Antitoxin |
| PVV54_RS24865 (PVV54_24865) | 5532934..5533287 | - | 354 | WP_274907727.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| PVV54_RS24870 (PVV54_24870) | 5533418..5535676 | - | 2259 | WP_274907728.1 | TonB-dependent siderophore receptor | - |
| PVV54_RS24875 (PVV54_24875) | 5535834..5536553 | + | 720 | WP_274907729.1 | response regulator transcription factor | - |
| PVV54_RS24880 (PVV54_24880) | 5536555..5537922 | + | 1368 | WP_274907730.1 | ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 5531679..5543853 | 12174 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13865.07 Da Isoelectric Point: 10.5129
>T273302 WP_274907727.1 NZ_CP118607:c5533287-5532934 [Pseudomonas sp. PSKL.D1]
MRVIAKAAVTKAIEAHARWRAPLSLWLTTFDRPSLRFDSFEQLRNTWAETSGWNVDRVPFSKLREPSRKGPLDIYIFDIR
KNECRIVTWINPRMGTIYIKAILSHPEYDKWCKSDIR
MRVIAKAAVTKAIEAHARWRAPLSLWLTTFDRPSLRFDSFEQLRNTWAETSGWNVDRVPFSKLREPSRKGPLDIYIFDIR
KNECRIVTWINPRMGTIYIKAILSHPEYDKWCKSDIR
Download Length: 354 bp
Antitoxin
Download Length: 158 a.a. Molecular weight: 17460.96 Da Isoelectric Point: 4.6719
>AT273302 WP_274907726.1 NZ_CP118607:c5532880-5532407 [Pseudomonas sp. PSKL.D1]
MKRDKIEATGLDAFIANISPMLQSLNNQVATMAQLLSACHEPIQDDADLQVRMALIDELYSHADSETHAAARFAEMVADR
VYDYESQTVLIPYASQSEALAFLMEERGVKQKDLSAIATQSAVSEILNSKRKMTVAQIKGFAEFFKVPVEFFMHGVV
MKRDKIEATGLDAFIANISPMLQSLNNQVATMAQLLSACHEPIQDDADLQVRMALIDELYSHADSETHAAARFAEMVADR
VYDYESQTVLIPYASQSEALAFLMEERGVKQKDLSAIATQSAVSEILNSKRKMTVAQIKGFAEFFKVPVEFFMHGVV
Download Length: 474 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|