Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3647031..3647647 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OU688_RS17570 Protein ID WP_001291435.1
Coordinates 3647429..3647647 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OU688_RS17565 Protein ID WP_000344800.1
Coordinates 3647031..3647405 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS17555 (3642120) 3642120..3643313 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OU688_RS17560 (3643336) 3643336..3646485 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OU688_RS17565 (3647031) 3647031..3647405 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OU688_RS17570 (3647429) 3647429..3647647 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OU688_RS17575 (3647819) 3647819..3648370 + 552 WP_000102568.1 maltose O-acetyltransferase -
OU688_RS17580 (3648486) 3648486..3648956 + 471 WP_000136192.1 YlaC family protein -
OU688_RS17585 (3649120) 3649120..3650670 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OU688_RS17590 (3650712) 3650712..3651065 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OU688_RS17600 (3651444) 3651444..3651755 + 312 WP_000409911.1 MGMT family protein -
OU688_RS17605 (3651786) 3651786..3652358 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T273282 WP_001291435.1 NZ_CP118601:3647429-3647647 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT273282 WP_000344800.1 NZ_CP118601:3647031-3647405 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References