Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2627671..2628309 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OU688_RS12660 Protein ID WP_000813794.1
Coordinates 2628133..2628309 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OU688_RS12655 Protein ID WP_001270286.1
Coordinates 2627671..2628087 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS12635 (2622823) 2622823..2623764 - 942 WP_001251315.1 ABC transporter permease -
OU688_RS12640 (2623765) 2623765..2624778 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
OU688_RS12645 (2624796) 2624796..2625941 - 1146 WP_113975712.1 ABC transporter substrate-binding protein -
OU688_RS12650 (2626186) 2626186..2627592 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
OU688_RS12655 (2627671) 2627671..2628087 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OU688_RS12660 (2628133) 2628133..2628309 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OU688_RS12665 (2628531) 2628531..2628761 + 231 WP_000494244.1 YncJ family protein -
OU688_RS12670 (2628853) 2628853..2630814 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OU688_RS12675 (2630887) 2630887..2631423 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OU688_RS12680 (2631515) 2631515..2632690 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T273281 WP_000813794.1 NZ_CP118601:c2628309-2628133 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT273281 WP_001270286.1 NZ_CP118601:c2628087-2627671 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References