273273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1418967..1419592 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag OU688_RS06900 Protein ID WP_000911329.1
Coordinates 1419194..1419592 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag OU688_RS06895 Protein ID WP_000450524.1
Coordinates 1418967..1419194 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS06870 (1414769) 1414769..1415239 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
OU688_RS06875 (1415239) 1415239..1415811 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
OU688_RS06880 (1415957) 1415957..1416835 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
OU688_RS06885 (1416852) 1416852..1417886 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
OU688_RS06890 (1418099) 1418099..1418812 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OU688_RS06895 (1418967) 1418967..1419194 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
OU688_RS06900 (1419194) 1419194..1419592 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
OU688_RS06905 (1419739) 1419739..1420602 + 864 WP_001267498.1 neutral zinc metallopeptidase -
OU688_RS06910 (1420617) 1420617..1422632 + 2016 WP_000829293.1 tRNA cytosine(34) acetyltransferase TmcA -
OU688_RS06915 (1422706) 1422706..1423404 + 699 WP_000679823.1 esterase -
OU688_RS06920 (1423514) 1423514..1423714 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T273273 WP_000911329.1 NZ_CP118601:1419194-1419592 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT273273 WP_000450524.1 NZ_CP118601:1418967-1419194 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References