Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 989500..990154 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag OU688_RS04860 Protein ID WP_113975638.1
Coordinates 989747..990154 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OU688_RS04855 Protein ID WP_000354046.1
Coordinates 989500..989766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS04830 (984788) 984788..985531 + 744 WP_000951964.1 SDR family oxidoreductase -
OU688_RS04835 (985588) 985588..987021 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
OU688_RS04840 (987066) 987066..987377 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
OU688_RS04845 (987541) 987541..988200 + 660 WP_000250274.1 hemolysin III family protein -
OU688_RS04850 (988277) 988277..989257 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OU688_RS04855 (989500) 989500..989766 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OU688_RS04860 (989747) 989747..990154 + 408 WP_113975638.1 protein YgfX Toxin
OU688_RS04865 (990194) 990194..990715 - 522 WP_001055874.1 flavodoxin FldB -
OU688_RS04870 (990827) 990827..991723 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OU688_RS04875 (991748) 991748..992458 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OU688_RS04880 (992464) 992464..994197 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15994.97 Da        Isoelectric Point: 10.5673

>T273271 WP_113975638.1 NZ_CP118601:989747-990154 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGCLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT273271 WP_000354046.1 NZ_CP118601:989500-989766 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References