Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 288673..289304 Replicon chromosome
Accession NZ_CP118601
Organism Escherichia coli strain NB4833

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OU688_RS01315 Protein ID WP_174785442.1
Coordinates 288673..288948 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag OU688_RS01320 Protein ID WP_000593555.1
Coordinates 288945..289304 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OU688_RS01300 (283677) 283677..284744 + 1068 WP_000361467.1 HlyD family secretion protein -
OU688_RS01305 (284741) 284741..287476 + 2736 WP_000149124.1 ribosome-associated ATPase/putative transporter RbbA -
OU688_RS01310 (287476) 287476..288600 + 1125 WP_001216257.1 ABC transporter permease -
OU688_RS01315 (288673) 288673..288948 + 276 WP_174785442.1 type II toxin-antitoxin system HicA family toxin Toxin
OU688_RS01320 (288945) 288945..289304 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OU688_RS01325 (289424) 289424..289825 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
OU688_RS01330 (289831) 289831..290637 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
OU688_RS01335 (290634) 290634..291398 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
OU688_RS01340 (291398) 291398..292231 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
OU688_RS01345 (292228) 292228..293172 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 281689..289825 8136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10141.86 Da        Isoelectric Point: 10.7076

>T273268 WP_174785442.1 NZ_CP118601:288673-288948 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVSQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT273268 WP_000593555.1 NZ_CP118601:288945-289304 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References