Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1486635..1487515 Replicon chromosome
Accession NZ_CP118598
Organism Bifidobacterium longum subsp. longum strain F2

Toxin (Protein)


Gene name relE Uniprot ID F8APN2
Locus tag PWA56_RS06780 Protein ID WP_007052625.1
Coordinates 1486635..1487126 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8APN1
Locus tag PWA56_RS06785 Protein ID WP_007057212.1
Coordinates 1487123..1487515 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA56_RS06760 (PWA56_06760) 1481744..1482949 + 1206 WP_010080850.1 histidine kinase -
PWA56_RS06765 (PWA56_06765) 1482984..1483709 + 726 WP_007056206.1 response regulator transcription factor -
PWA56_RS06770 (PWA56_06770) 1483749..1484390 + 642 WP_165502129.1 GNAT family N-acetyltransferase -
PWA56_RS06775 (PWA56_06775) 1484480..1486585 + 2106 WP_007052626.1 DUF262 domain-containing protein -
PWA56_RS06780 (PWA56_06780) 1486635..1487126 - 492 WP_007052625.1 type II toxin-antitoxin system VapC family toxin Toxin
PWA56_RS06785 (PWA56_06785) 1487123..1487515 - 393 WP_007057212.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PWA56_RS06790 (PWA56_06790) 1487660..1490359 - 2700 WP_116464084.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-61)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18531.70 Da        Isoelectric Point: 6.2348

>T273267 WP_007052625.1 NZ_CP118598:c1487126-1486635 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDVFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15147.29 Da        Isoelectric Point: 5.8624

>AT273267 WP_007057212.1 NZ_CP118598:c1487515-1487123 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8APN2

Antitoxin

Source ID Structure
AlphaFold DB F8APN1

References