Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4684531..4685519 Replicon chromosome
Accession NC_017633
Organism Escherichia coli ETEC H10407

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag ETEC_RS23440 Protein ID WP_014640052.1
Coordinates 4685133..4685519 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0J5Z6D5
Locus tag ETEC_RS23435 Protein ID WP_000458584.1
Coordinates 4684531..4685103 (+) Length 191 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETEC_RS23410 4679614..4680222 + 609 WP_000646078.1 transcriptional repressor LexA -
ETEC_RS23415 4680295..4681620 + 1326 WP_001326646.1 MATE family efflux transporter DinF -
ETEC_RS23420 4681736..4681945 + 210 WP_001030593.1 CsbD family protein -
ETEC_RS23425 4681987..4682502 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
ETEC_RS23430 4682820..4683812 + 993 WP_000912573.1 DUF2713 family protein -
ETEC_RS29045 4684173..4684295 + 123 WP_001300034.1 hypothetical protein -
ETEC_RS23435 4684531..4685103 + 573 WP_000458584.1 SocA family protein Antitoxin
ETEC_RS23440 4685133..4685519 + 387 WP_014640052.1 hypothetical protein Toxin
ETEC_RS31065 4685559..4685732 + 174 WP_000390070.1 hypothetical protein -
ETEC_RS23445 4685871..4686905 + 1035 WP_001128526.1 hypothetical protein -
ETEC_RS23450 4687098..4687379 - 282 WP_001093922.1 pyocin activator PrtN family protein -
ETEC_RS23455 4687416..4687988 - 573 WP_001061351.1 3'-5' exoribonuclease -
ETEC_RS23460 4687988..4688797 - 810 WP_000206747.1 hypothetical protein -
ETEC_RS23465 4688797..4689159 - 363 WP_001242732.1 phage protein -
ETEC_RS23470 4689150..4689686 - 537 WP_000008232.1 5'-deoxynucleotidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4679614..4727871 48257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(27-137)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T27325 WP_014640052.1 NC_017633:4685133-4685519 [Escherichia coli ETEC H10407]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T27325 NC_017633:4685133-4685519 [Escherichia coli ETEC H10407]
GTGCTTGCCCCAACTGGACCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTTTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21973.21 Da        Isoelectric Point: 6.0283

>AT27325 WP_000458584.1 NC_017633:4684531-4685103 [Escherichia coli ETEC H10407]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT27325 NC_017633:4684531-4685103 [Escherichia coli ETEC H10407]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGAGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAATT
GAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATTTGATCTCGCAAATATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGTTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0J5Z6D5

References