Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3895614..3896395 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag PXV21_RS18670 Protein ID WP_022649378.1
Coordinates 3895614..3896105 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag PXV21_RS18675 Protein ID WP_022649379.1
Coordinates 3896102..3896395 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS18655 (PXV21_18655) 3890894..3891346 - 453 WP_022649375.1 hypothetical protein -
PXV21_RS18660 (PXV21_18660) 3891861..3893771 + 1911 WP_022649376.1 hypothetical protein -
PXV21_RS18665 (PXV21_18665) 3893768..3895462 + 1695 WP_022649377.1 hypothetical protein -
PXV21_RS18670 (PXV21_18670) 3895614..3896105 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
PXV21_RS18675 (PXV21_18675) 3896102..3896395 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
PXV21_RS18680 (PXV21_18680) 3896497..3898290 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
PXV21_RS18685 (PXV21_18685) 3898287..3898919 - 633 WP_022649381.1 response regulator transcription factor -
PXV21_RS18690 (PXV21_18690) 3899095..3899409 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T273240 WP_022649378.1 NZ_CP118567:c3896105-3895614 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT273240 WP_022649379.1 NZ_CP118567:c3896395-3896102 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References