Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3802676..3803333 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag PXV21_RS18195 Protein ID WP_022649305.1
Coordinates 3802676..3803086 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PXV21_RS18200 Protein ID WP_003863437.1
Coordinates 3803067..3803333 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS18175 (PXV21_18175) 3798674..3800407 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
PXV21_RS18180 (PXV21_18180) 3800413..3801126 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PXV21_RS18185 (PXV21_18185) 3801155..3802051 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PXV21_RS18190 (PXV21_18190) 3802153..3802674 + 522 WP_015571793.1 flavodoxin FldB -
PXV21_RS18195 (PXV21_18195) 3802676..3803086 - 411 WP_022649305.1 protein YgfX Toxin
PXV21_RS18200 (PXV21_18200) 3803067..3803333 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PXV21_RS18205 (PXV21_18205) 3803628..3804608 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
PXV21_RS18210 (PXV21_18210) 3805132..3805791 - 660 WP_022649307.1 hemolysin III family protein -
PXV21_RS18215 (PXV21_18215) 3806058..3806789 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T273239 WP_022649305.1 NZ_CP118567:c3803086-3802676 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT273239 WP_003863437.1 NZ_CP118567:c3803333-3803067 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References