Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3520854..3521593 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag PXV21_RS16830 Protein ID WP_022649088.1
Coordinates 3521213..3521593 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag PXV21_RS16825 Protein ID WP_022649087.1
Coordinates 3520854..3521180 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS16810 (PXV21_16810) 3516748..3519408 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
PXV21_RS16815 (PXV21_16815) 3520038..3520361 + 324 WP_022649085.1 antirestriction protein -
PXV21_RS16820 (PXV21_16820) 3520376..3520843 + 468 WP_022649086.1 DNA repair protein RadC -
PXV21_RS16825 (PXV21_16825) 3520854..3521180 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PXV21_RS16830 (PXV21_16830) 3521213..3521593 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
PXV21_RS16835 (PXV21_16835) 3521590..3521817 + 228 WP_022649089.1 DUF5983 family protein -
PXV21_RS16840 (PXV21_16840) 3522209..3522502 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
PXV21_RS16845 (PXV21_16845) 3522846..3524162 - 1317 WP_022649091.1 amidase family protein -
PXV21_RS16850 (PXV21_16850) 3524217..3525512 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3497745..3522502 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T273238 WP_022649088.1 NZ_CP118567:3521213-3521593 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT273238 WP_022649087.1 NZ_CP118567:3520854-3521180 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References