Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2226725..2227464 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag PXV21_RS10600 Protein ID WP_022648141.1
Coordinates 2226725..2227210 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PXV21_RS10605 Protein ID WP_003857131.1
Coordinates 2227198..2227464 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS10575 (PXV21_10575) 2222881..2223903 + 1023 WP_022648135.1 alpha/beta hydrolase -
PXV21_RS10580 (PXV21_10580) 2223999..2224763 + 765 WP_022648136.1 SDR family oxidoreductase -
PXV21_RS10585 (PXV21_10585) 2225430..2225693 + 264 WP_022648138.1 DUF4225 domain-containing protein -
PXV21_RS10590 (PXV21_10590) 2225668..2225997 - 330 WP_022648139.1 hypothetical protein -
PXV21_RS10595 (PXV21_10595) 2226130..2226699 + 570 WP_022648140.1 hypothetical protein -
PXV21_RS10600 (PXV21_10600) 2226725..2227210 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
PXV21_RS10605 (PXV21_10605) 2227198..2227464 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PXV21_RS10610 (PXV21_10610) 2227528..2228457 - 930 WP_022648142.1 LysR family transcriptional regulator -
PXV21_RS10615 (PXV21_10615) 2228587..2229975 + 1389 WP_022648143.1 MFS transporter -
PXV21_RS10620 (PXV21_10620) 2229954..2230511 - 558 WP_022648144.1 OmpH family outer membrane protein -
PXV21_RS10625 (PXV21_10625) 2230632..2231768 - 1137 WP_022648145.1 type 1 fimbrial protein -
PXV21_RS10630 (PXV21_10630) 2231792..2232370 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2203858..2227464 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T273233 WP_022648141.1 NZ_CP118567:c2227210-2226725 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT273233 WP_003857131.1 NZ_CP118567:c2227464-2227198 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References