Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1081753..1082374 Replicon chromosome
Accession NZ_CP118567
Organism Enterobacter hormaechei strain 2020CK-00199

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PXV21_RS05150 Protein ID WP_015571250.1
Coordinates 1081753..1081971 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PXV21_RS05155 Protein ID WP_006809850.1
Coordinates 1082000..1082374 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV21_RS05120 (PXV21_05120) 1077765..1078025 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
PXV21_RS05125 (PXV21_05125) 1078028..1078168 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PXV21_RS05130 (PXV21_05130) 1078165..1078875 - 711 WP_022647267.1 GNAT family protein -
PXV21_RS05135 (PXV21_05135) 1078978..1080438 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
PXV21_RS05140 (PXV21_05140) 1080410..1080877 - 468 WP_022647269.1 YlaC family protein -
PXV21_RS05145 (PXV21_05145) 1080994..1081545 - 552 WP_022647270.1 maltose O-acetyltransferase -
PXV21_RS05150 (PXV21_05150) 1081753..1081971 - 219 WP_015571250.1 HHA domain-containing protein Toxin
PXV21_RS05155 (PXV21_05155) 1082000..1082374 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PXV21_RS05160 (PXV21_05160) 1082884..1086030 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit AcrB -
PXV21_RS05165 (PXV21_05165) 1086053..1087246 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T273232 WP_015571250.1 NZ_CP118567:c1081971-1081753 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT273232 WP_006809850.1 NZ_CP118567:c1082374-1082000 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References