Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3725438..3726014 Replicon chromosome
Accession NZ_CP118552
Organism Enterobacter hormaechei strain 2020CK-00206

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag PWP98_RS17775 Protein ID WP_015572580.1
Coordinates 3725727..3726014 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag PWP98_RS17770 Protein ID WP_017694570.1
Coordinates 3725438..3725740 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWP98_RS17750 (PWP98_17750) 3721735..3722280 + 546 WP_006810254.1 YfaZ family outer membrane protein -
PWP98_RS17755 (PWP98_17755) 3722456..3723826 - 1371 WP_047745287.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PWP98_RS17760 (PWP98_17760) 3723980..3724732 + 753 WP_047745285.1 AraC family transcriptional regulator -
PWP98_RS17765 (PWP98_17765) 3724771..3725409 + 639 WP_047736941.1 LysE family translocator -
PWP98_RS17770 (PWP98_17770) 3725438..3725740 - 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
PWP98_RS17775 (PWP98_17775) 3725727..3726014 - 288 WP_015572580.1 BrnT family toxin Toxin
PWP98_RS17780 (PWP98_17780) 3726184..3727455 + 1272 WP_047745284.1 DUF445 domain-containing protein -
PWP98_RS17785 (PWP98_17785) 3727452..3728528 - 1077 WP_015572578.1 DUF2955 domain-containing protein -
PWP98_RS17790 (PWP98_17790) 3728518..3729585 - 1068 WP_116293634.1 HlyD family secretion protein -
PWP98_RS17795 (PWP98_17795) 3729582..3730052 - 471 WP_015572576.1 MarR family transcriptional regulator -
PWP98_RS17800 (PWP98_17800) 3730202..3730897 - 696 WP_032647138.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T273226 WP_015572580.1 NZ_CP118552:c3726014-3725727 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT273226 WP_017694570.1 NZ_CP118552:c3725740-3725438 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References