Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 103848..105431 Replicon chromosome
Accession NZ_CP118547
Organism Stenotrophomonas maltophilia strain HT2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PWE35_RS00445 Protein ID WP_038646246.1
Coordinates 103848..105170 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PWE35_RS00450 Protein ID WP_274849988.1
Coordinates 105174..105431 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWE35_RS00430 (PWE35_00430) 99698..101329 - 1632 WP_005407531.1 TldD/PmbA family protein -
PWE35_RS00435 (PWE35_00435) 101668..102582 - 915 WP_012479096.1 IS110-like element ISStma7 family transposase -
PWE35_RS00440 (PWE35_00440) 103233..103847 + 615 WP_005407532.1 DUF938 domain-containing protein -
PWE35_RS00445 (PWE35_00445) 103848..105170 - 1323 WP_038646246.1 type II toxin-antitoxin system HipA family toxin Toxin
PWE35_RS00450 (PWE35_00450) 105174..105431 - 258 WP_274849988.1 helix-turn-helix transcriptional regulator Antitoxin
PWE35_RS00455 (PWE35_00455) 105593..109279 - 3687 WP_274849989.1 indolepyruvate ferredoxin oxidoreductase family protein -
PWE35_RS00460 (PWE35_00460) 109451..110086 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 101668..102582 914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49039.94 Da        Isoelectric Point: 6.9606

>T273215 WP_038646246.1 NZ_CP118547:c105170-103848 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9612.00 Da        Isoelectric Point: 11.8468

>AT273215 WP_274849988.1 NZ_CP118547:c105431-105174 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRNPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References