Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 200372..201008 Replicon chromosome
Accession NZ_CP118545
Organism Priestia aryabhattai strain G5.MM8

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag PWC21_RS01135 Protein ID WP_013055004.1
Coordinates 200658..201008 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag PWC21_RS01130 Protein ID WP_013055003.1
Coordinates 200372..200653 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWC21_RS01105 (PWC21_01105) 195738..196709 + 972 WP_033580801.1 UV DNA damage repair endonuclease UvsE -
PWC21_RS01110 (PWC21_01110) 196718..197320 - 603 WP_274863137.1 rhomboid family intramembrane serine protease -
PWC21_RS01115 (PWC21_01115) 197385..197750 + 366 WP_028411881.1 holo-ACP synthase -
PWC21_RS01120 (PWC21_01120) 197809..198867 + 1059 WP_033580802.1 outer membrane lipoprotein carrier protein LolA -
PWC21_RS01125 (PWC21_01125) 198981..200171 + 1191 WP_274863138.1 alanine racemase -
PWC21_RS01130 (PWC21_01130) 200372..200653 + 282 WP_013055003.1 hypothetical protein Antitoxin
PWC21_RS01135 (PWC21_01135) 200658..201008 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PWC21_RS01140 (PWC21_01140) 201166..202002 + 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
PWC21_RS01145 (PWC21_01145) 202005..202361 + 357 WP_013055006.1 STAS domain-containing protein -
PWC21_RS01150 (PWC21_01150) 202365..202766 + 402 WP_013055007.1 anti-sigma regulatory factor -
PWC21_RS01155 (PWC21_01155) 202780..203790 + 1011 WP_013055008.1 PP2C family protein-serine/threonine phosphatase -
PWC21_RS01160 (PWC21_01160) 203850..204182 + 333 WP_013055009.1 anti-sigma factor antagonist -
PWC21_RS01165 (PWC21_01165) 204179..204664 + 486 WP_025753516.1 anti-sigma B factor RsbW -
PWC21_RS01170 (PWC21_01170) 204630..205424 + 795 WP_013055011.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T273214 WP_013055004.1 NZ_CP118545:200658-201008 [Priestia aryabhattai]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT273214 WP_013055003.1 NZ_CP118545:200372-200653 [Priestia aryabhattai]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References