Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 532011..532664 Replicon chromosome
Accession NZ_CP118544
Organism Brevibacillus parabrevis strain BCP-09

Toxin (Protein)


Gene name mazF Uniprot ID J2PLP3
Locus tag PSE45_RS02875 Protein ID WP_005830205.1
Coordinates 532314..532664 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3M8AYL7
Locus tag PSE45_RS02870 Protein ID WP_025845698.1
Coordinates 532011..532310 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSE45_RS02850 (PSE45_02850) 527281..528318 + 1038 WP_122966581.1 outer membrane lipoprotein-sorting protein -
PSE45_RS02855 (PSE45_02855) 528517..529965 + 1449 WP_122966580.1 hypothetical protein -
PSE45_RS02860 (PSE45_02860) 530187..530627 + 441 WP_122966579.1 hypothetical protein -
PSE45_RS02865 (PSE45_02865) 530630..531832 + 1203 WP_173599859.1 alanine racemase -
PSE45_RS02870 (PSE45_02870) 532011..532310 + 300 WP_025845698.1 CopG family ribbon-helix-helix protein Antitoxin
PSE45_RS02875 (PSE45_02875) 532314..532664 + 351 WP_005830205.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSE45_RS02880 (PSE45_02880) 532970..533326 + 357 WP_229049930.1 anti-sigma regulatory factor -
PSE45_RS02885 (PSE45_02885) 533320..534321 + 1002 WP_122966576.1 PP2C family protein-serine/threonine phosphatase -
PSE45_RS02890 (PSE45_02890) 534347..534673 + 327 WP_063229461.1 anti-sigma factor antagonist -
PSE45_RS02895 (PSE45_02895) 534673..535167 + 495 WP_122966575.1 anti-sigma B factor RsbW -
PSE45_RS02900 (PSE45_02900) 535136..535933 + 798 WP_122966574.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-52)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.86 Da        Isoelectric Point: 4.8435

>T273213 WP_005830205.1 NZ_CP118544:532314-532664 [Brevibacillus parabrevis]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11323.26 Da        Isoelectric Point: 10.3594

>AT273213 WP_025845698.1 NZ_CP118544:532011-532310 [Brevibacillus parabrevis]
MVGGGFVLSKSNTKRIMISLPQHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRTIRETMQKGYMEMAKINLKMASE
AFGAEEEADHTLVRLVSGV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2PLP3

Antitoxin

Source ID Structure
AlphaFold DB A0A3M8AYL7

References