Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4193134..4193915 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag PWA52_RS20490 Protein ID WP_000626100.1
Coordinates 4193134..4193625 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PWA52_RS20495 Protein ID WP_001110452.1
Coordinates 4193622..4193915 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS20455 (4188594) 4188594..4188941 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PWA52_RS20460 (4188917) 4188917..4190620 + 1704 WP_079786765.1 protein-disulfide reductase DsbD -
PWA52_RS20465 (4190657) 4190657..4191232 + 576 WP_001188509.1 transcriptional regulator -
PWA52_RS20475 (4191503) 4191503..4191577 - 75 Protein_4014 helix-turn-helix domain-containing protein -
PWA52_RS20480 (4191957) 4191957..4192034 + 78 Protein_4015 porin family protein -
PWA52_RS20485 (4192134) 4192134..4192886 + 753 WP_000842432.1 non-specific acid phosphatase -
PWA52_RS20490 (4193134) 4193134..4193625 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
PWA52_RS20495 (4193622) 4193622..4193915 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PWA52_RS20500 (4194232) 4194232..4194453 + 222 WP_001576552.1 hypothetical protein -
PWA52_RS20505 (4194718) 4194718..4195593 + 876 WP_000921680.1 AraC family transcriptional regulator -
PWA52_RS20510 (4195590) 4195590..4195877 + 288 WP_001541332.1 transcriptional regulator RtsB -
PWA52_RS20515 (4195870) 4195870..4196178 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
PWA52_RS20520 (4196177) 4196177..4196425 + 249 Protein_4023 Ig-like domain-containing protein -
PWA52_RS20525 (4196537) 4196537..4196668 + 132 Protein_4024 hypothetical protein -
PWA52_RS20530 (4196958) 4196958..4197860 - 903 WP_020937303.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T273208 WP_000626100.1 NZ_CP118542:c4193625-4193134 [Salmonella sp. CVCC 1806]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT273208 WP_001110452.1 NZ_CP118542:c4193915-4193622 [Salmonella sp. CVCC 1806]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References