Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4086230..4086746 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name relE Uniprot ID A0A756PF38
Locus tag PWA52_RS19915 Protein ID WP_000220583.1
Coordinates 4086230..4086514 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PWA52_RS19920 Protein ID WP_000212724.1
Coordinates 4086504..4086746 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS19900 (4081445) 4081445..4083093 + 1649 Protein_3903 alpha,alpha-phosphotrehalase -
PWA52_RS19905 (4083502) 4083502..4085640 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PWA52_RS19910 (4085762) 4085762..4086226 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PWA52_RS19915 (4086230) 4086230..4086514 - 285 WP_000220583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWA52_RS19920 (4086504) 4086504..4086746 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PWA52_RS19925 (4086824) 4086824..4088737 - 1914 WP_001212128.1 BglG family transcription antiterminator -
PWA52_RS19930 (4088754) 4088754..4089494 - 741 WP_000779259.1 KDGP aldolase family protein -
PWA52_RS19935 (4089491) 4089491..4090609 - 1119 WP_269724545.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PWA52_RS19940 (4090593) 4090593..4091726 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10896.62 Da        Isoelectric Point: 9.6743

>T273207 WP_000220583.1 NZ_CP118542:c4086514-4086230 [Salmonella sp. CVCC 1806]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDPPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT273207 WP_000212724.1 NZ_CP118542:c4086746-4086504 [Salmonella sp. CVCC 1806]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A756PF38

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References