Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4001480..4002056 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PWA52_RS19490 Protein ID WP_001131963.1
Coordinates 4001769..4002056 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PWA52_RS19485 Protein ID WP_000063142.1
Coordinates 4001480..4001782 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS19470 (3998434) 3998434..4000122 + 1689 Protein_3818 pyruvate/proton symporter BtsT -
PWA52_RS19475 (4000235) 4000235..4000438 + 204 WP_000460616.1 YbdD/YjiX family protein -
PWA52_RS19480 (4000449) 4000449..4001405 + 957 WP_000187842.1 GTPase -
PWA52_RS19485 (4001480) 4001480..4001782 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PWA52_RS19490 (4001769) 4001769..4002056 - 288 WP_001131963.1 BrnT family toxin Toxin
PWA52_RS19495 (4002452) 4002452..4004292 + 1841 Protein_3823 3'-5' exonuclease -
PWA52_RS19500 (4004905) 4004905..4005324 + 420 WP_001720162.1 restriction endonuclease subunit S -
PWA52_RS19505 (4005483) 4005483..4006736 + 1254 WP_001206756.1 N-6 DNA methylase -
PWA52_RS19510 (4006768) 4006768..4006902 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T273205 WP_001131963.1 NZ_CP118542:c4002056-4001769 [Salmonella sp. CVCC 1806]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT273205 WP_000063142.1 NZ_CP118542:c4001782-4001480 [Salmonella sp. CVCC 1806]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References