Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3367261..3367881 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PWA52_RS16380 Protein ID WP_001280991.1
Coordinates 3367663..3367881 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6C6Z3Y6
Locus tag PWA52_RS16375 Protein ID WP_000344806.1
Coordinates 3367261..3367635 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS16365 (3362400) 3362400..3363593 + 1194 WP_020937096.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PWA52_RS16370 (3363616) 3363616..3366765 + 3150 WP_020937097.1 efflux RND transporter permease AcrB -
PWA52_RS16375 (3367261) 3367261..3367635 + 375 WP_000344806.1 Hha toxicity modulator TomB Antitoxin
PWA52_RS16380 (3367663) 3367663..3367881 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PWA52_RS16385 (3368060) 3368060..3368611 + 552 WP_001278793.1 maltose O-acetyltransferase -
PWA52_RS16390 (3368729) 3368729..3369199 + 471 WP_079786716.1 YlaC family protein -
PWA52_RS16395 (3369255) 3369255..3369395 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PWA52_RS16400 (3369397) 3369397..3369663 - 267 WP_020937098.1 type B 50S ribosomal protein L31 -
PWA52_RS16405 (3369888) 3369888..3371438 + 1551 WP_000213140.1 EAL domain-containing protein -
PWA52_RS16415 (3371669) 3371669..3372058 + 390 WP_000961288.1 MGMT family protein -
PWA52_RS16420 (3372091) 3372091..3372660 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T273202 WP_001280991.1 NZ_CP118542:3367663-3367881 [Salmonella sp. CVCC 1806]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14425.25 Da        Isoelectric Point: 5.1444

>AT273202 WP_000344806.1 NZ_CP118542:3367261-3367635 [Salmonella sp. CVCC 1806]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATKANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z3Y6

References