Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3483885..3484717 Replicon chromosome
Accession NC_017633
Organism Escherichia coli ETEC H10407

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag ETEC_RS17550 Protein ID WP_000854753.1
Coordinates 3484343..3484717 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag ETEC_RS17545 Protein ID WP_001278232.1
Coordinates 3483885..3484253 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETEC_RS17510 3480704..3481159 + 456 WP_000581512.1 hypothetical protein -
ETEC_RS17515 3481238..3481471 + 234 WP_001119729.1 DUF905 family protein -
ETEC_RS17520 3481571..3482389 + 819 WP_001234631.1 DUF945 domain-containing protein -
ETEC_RS17525 3482471..3482950 + 480 WP_000860065.1 antirestriction protein -
ETEC_RS17530 3482962..3483438 + 477 WP_014640014.1 RadC family protein -
ETEC_RS17535 3483501..3483722 + 222 WP_000692303.1 DUF987 domain-containing protein -
ETEC_RS17545 3483885..3484253 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
ETEC_RS17550 3484343..3484717 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
ETEC_RS17555 3484714..3485202 + 489 WP_000777541.1 hypothetical protein -
ETEC_RS17560 3485214..3485411 + 198 WP_000839281.1 DUF957 domain-containing protein -
ETEC_RS17565 3485508..3486077 + 570 WP_001290243.1 DUF4942 domain-containing protein -
ETEC_RS17570 3486358..3486894 - 537 WP_000942783.1 GspM family type II secretion system protein YghD -
ETEC_RS17575 3486896..3488074 - 1179 WP_000094962.1 type II secretion system protein GspL -
ETEC_RS17580 3488071..3489048 - 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
ETEC_RS17585 3489051..3489650 - 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T27320 WP_000854753.1 NC_017633:3484343-3484717 [Escherichia coli ETEC H10407]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T27320 NC_017633:3484343-3484717 [Escherichia coli ETEC H10407]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT27320 WP_001278232.1 NC_017633:3483885-3484253 [Escherichia coli ETEC H10407]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT27320 NC_017633:3483885-3484253 [Escherichia coli ETEC H10407]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References