Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 983187..984001 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name TacT3 Uniprot ID B5RDM7
Locus tag PWA52_RS04730 Protein ID WP_000971654.1
Coordinates 983187..983714 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PWA52_RS04735 Protein ID WP_000855694.1
Coordinates 983711..984001 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS04705 (979476) 979476..979874 + 399 Protein_921 cytoplasmic protein -
PWA52_RS04710 (980460) 980460..981128 + 669 WP_000445914.1 hypothetical protein -
PWA52_RS04715 (981155) 981155..981649 + 495 WP_000424949.1 hypothetical protein -
PWA52_RS04720 (981894) 981894..982550 - 657 WP_000420455.1 protein-serine/threonine phosphatase -
PWA52_RS04725 (982909) 982909..983114 + 206 Protein_925 IS5/IS1182 family transposase -
PWA52_RS04730 (983187) 983187..983714 - 528 WP_000971654.1 GNAT family N-acetyltransferase Toxin
PWA52_RS04735 (983711) 983711..984001 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PWA52_RS04740 (984271) 984271..984460 - 190 Protein_928 IS3 family transposase -
PWA52_RS04745 (984864) 984864..985307 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PWA52_RS04750 (985763) 985763..986413 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
PWA52_RS04755 (986410) 986410..988098 + 1689 WP_000848115.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 982938..983114 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.85 Da        Isoelectric Point: 9.6420

>T273197 WP_000971654.1 NZ_CP118542:c983714-983187 [Salmonella sp. CVCC 1806]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT273197 WP_000855694.1 NZ_CP118542:c984001-983711 [Salmonella sp. CVCC 1806]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y9PNF0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References