Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 831469..832094 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PWA52_RS04035 Protein ID WP_000911336.1
Coordinates 831696..832094 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PWA52_RS04030 Protein ID WP_000557549.1
Coordinates 831469..831696 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS04000 (826475) 826475..827994 + 1520 Protein_783 lysine--tRNA ligase -
PWA52_RS04005 (828070) 828070..828615 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PWA52_RS04010 (828880) 828880..829638 + 759 WP_020937168.1 amidase activator ActS -
PWA52_RS04020 (829923) 829923..830729 - 807 WP_001574939.1 DUF1460 domain-containing protein -
PWA52_RS04025 (831009) 831009..831260 - 252 WP_001576352.1 hypothetical protein -
PWA52_RS04030 (831469) 831469..831696 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PWA52_RS04035 (831696) 831696..832094 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PWA52_RS04040 (832902) 832902..833438 + 537 WP_079786800.1 STM3031 family outer membrane protein -
PWA52_RS04045 (833485) 833485..834117 + 633 WP_000835265.1 YfdX family protein -
PWA52_RS04050 (834836) 834836..835417 + 582 WP_001747403.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 829923..841284 11361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T273196 WP_000911336.1 NZ_CP118542:831696-832094 [Salmonella sp. CVCC 1806]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT273196 WP_000557549.1 NZ_CP118542:831469-831696 [Salmonella sp. CVCC 1806]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References