Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 196205..196965 Replicon chromosome
Accession NZ_CP118542
Organism Salmonella sp. CVCC 1806

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PWA52_RS00925 Protein ID WP_000533909.1
Coordinates 196480..196965 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PWA52_RS00920 Protein ID WP_000965886.1
Coordinates 196205..196492 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA52_RS00900 (191610) 191610..192521 + 912 WP_269724494.1 glycine--tRNA ligase subunit alpha -
PWA52_RS00905 (192531) 192531..194600 + 2070 WP_001291748.1 glycine--tRNA ligase subunit beta -
PWA52_RS00910 (194990) 194990..195388 + 399 Protein_180 IS3 family transposase -
PWA52_RS00915 (195560) 195560..196027 + 468 Protein_181 GNAT family N-acetyltransferase -
PWA52_RS00920 (196205) 196205..196492 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PWA52_RS00925 (196480) 196480..196965 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PWA52_RS00930 (197336) 197336..197875 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
PWA52_RS00935 (198049) 198049..198261 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PWA52_RS00940 (198549) 198549..198839 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PWA52_RS00945 (199278) 199278..199988 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PWA52_RS00950 (200038) 200038..201000 - 963 WP_000804673.1 glyoxylate/hydroxypyruvate reductase GhrB -
PWA52_RS00955 (201219) 201219..201881 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T273192 WP_000533909.1 NZ_CP118542:196480-196965 [Salmonella sp. CVCC 1806]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT273192 WP_000965886.1 NZ_CP118542:196205-196492 [Salmonella sp. CVCC 1806]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References