Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2530444..2531055 Replicon chromosome
Accession NZ_CP118539
Organism Xylella fastidiosa strain ICMP 15197

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag PXH81_RS11475 Protein ID WP_011098375.1
Coordinates 2530756..2531055 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag PXH81_RS11470 Protein ID WP_004085003.1
Coordinates 2530444..2530752 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXH81_RS11440 (PXH81_11440) 2527023..2527784 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
PXH81_RS11465 (PXH81_11465) 2528976..2530370 + 1395 WP_274849809.1 hypothetical protein -
PXH81_RS11470 (PXH81_11470) 2530444..2530752 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
PXH81_RS11475 (PXH81_11475) 2530756..2531055 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXH81_RS11480 (PXH81_11480) 2531143..2531688 + 546 WP_011098376.1 hypothetical protein -
PXH81_RS11485 (PXH81_11485) 2531700..2531843 + 144 WP_155115087.1 hypothetical protein -
PXH81_RS11490 (PXH81_11490) 2531996..2532376 - 381 WP_004089371.1 DUF596 domain-containing protein -
PXH81_RS11495 (PXH81_11495) 2532381..2533511 - 1131 WP_012382788.1 DUF769 domain-containing protein -
PXH81_RS11500 (PXH81_11500) 2533819..2534199 - 381 WP_004087391.1 DUF596 domain-containing protein -
PXH81_RS11505 (PXH81_11505) 2534211..2535572 - 1362 WP_272819646.1 hemagglutinin -
PXH81_RS11510 (PXH81_11510) 2535652..2535795 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2481278..2531505 50227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T273188 WP_011098375.1 NZ_CP118539:c2531055-2530756 [Xylella fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT273188 WP_004085003.1 NZ_CP118539:c2530752-2530444 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References