Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1318496..1319027 Replicon chromosome
Accession NZ_CP118539
Organism Xylella fastidiosa strain ICMP 15197

Toxin (Protein)


Gene name relE Uniprot ID Q87CH1
Locus tag PXH81_RS06015 Protein ID WP_004090909.1
Coordinates 1318746..1319027 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q87CH2
Locus tag PXH81_RS06010 Protein ID WP_004090907.1
Coordinates 1318496..1318759 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXH81_RS05985 (PXH81_05985) 1313722..1314900 - 1179 WP_011097931.1 phage tail sheath family protein -
PXH81_RS05990 (PXH81_05990) 1314965..1316557 - 1593 WP_012382617.1 tail fiber domain-containing protein -
PXH81_RS05995 (PXH81_05995) 1316565..1317122 - 558 WP_011097610.1 phage tail protein I -
PXH81_RS06000 (PXH81_06000) 1317115..1318008 - 894 WP_274265311.1 baseplate J/gp47 family protein -
PXH81_RS06005 (PXH81_06005) 1318008..1318370 - 363 WP_014607615.1 GPW/gp25 family protein -
PXH81_RS06010 (PXH81_06010) 1318496..1318759 + 264 WP_004090907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PXH81_RS06015 (PXH81_06015) 1318746..1319027 + 282 WP_004090909.1 type II toxin-antitoxin system YafQ family toxin Toxin
PXH81_RS06020 (PXH81_06020) 1319064..1319651 - 588 WP_011097612.1 phage baseplate assembly protein V -
PXH81_RS06025 (PXH81_06025) 1319648..1320190 - 543 WP_011097613.1 hypothetical protein -
PXH81_RS06030 (PXH81_06030) 1320166..1320687 - 522 WP_011097614.1 hypothetical protein -
PXH81_RS06035 (PXH81_06035) 1320684..1321007 - 324 WP_011097935.1 hypothetical protein -
PXH81_RS06040 (PXH81_06040) 1321007..1321267 - 261 WP_011097616.1 hypothetical protein -
PXH81_RS06045 (PXH81_06045) 1321285..1323159 - 1875 WP_038232803.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1305083..1352368 47285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10936.37 Da        Isoelectric Point: 7.2205

>T273186 WP_004090909.1 NZ_CP118539:1318746-1319027 [Xylella fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9495.95 Da        Isoelectric Point: 5.6033

>AT273186 WP_004090907.1 NZ_CP118539:1318496-1318759 [Xylella fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87CH1

Antitoxin

Source ID Structure
AlphaFold DB Q87CH2

References