Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4279945..4280726 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag O1A30_RS21175 Protein ID WP_000626103.1
Coordinates 4279945..4280436 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag O1A30_RS21180 Protein ID WP_001110456.1
Coordinates 4280433..4280726 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS21150 (O1A30_21150) 4275712..4277076 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
O1A30_RS21155 (O1A30_21155) 4277073..4278107 - 1035 WP_001195363.1 ParA family protein -
O1A30_RS21160 (O1A30_21160) 4278321..4278395 - 75 Protein_4148 helix-turn-helix domain-containing protein -
O1A30_RS21165 (O1A30_21165) 4278775..4278852 + 78 Protein_4149 porin family protein -
O1A30_RS21170 (O1A30_21170) 4278952..4279704 + 753 WP_001785756.1 non-specific acid phosphatase -
O1A30_RS21175 (O1A30_21175) 4279945..4280436 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
O1A30_RS21180 (O1A30_21180) 4280433..4280726 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
O1A30_RS21185 (O1A30_21185) 4281043..4281265 + 223 Protein_4153 hypothetical protein -
O1A30_RS21190 (O1A30_21190) 4281531..4282406 + 876 WP_000921674.1 AraC family transcriptional regulator -
O1A30_RS21195 (O1A30_21195) 4282403..4282690 + 288 WP_001269916.1 transcriptional regulator RtsB -
O1A30_RS21200 (O1A30_21200) 4282713..4282929 + 217 Protein_4156 hypothetical protein -
O1A30_RS21205 (O1A30_21205) 4282937..4283281 + 345 WP_100680417.1 Ig-like domain-containing protein -
O1A30_RS21210 (O1A30_21210) 4283568..4284473 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T273176 WP_000626103.1 NZ_CP118537:c4280436-4279945 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT273176 WP_001110456.1 NZ_CP118537:c4280726-4280433 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References