Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4157557..4158335 | Replicon | chromosome |
| Accession | NZ_CP118537 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain S3 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1C2 |
| Locus tag | O1A30_RS20470 | Protein ID | WP_000622308.1 |
| Coordinates | 4157557..4158045 (-) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1C3 |
| Locus tag | O1A30_RS20475 | Protein ID | WP_001143724.1 |
| Coordinates | 4158042..4158335 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O1A30_RS20455 (O1A30_20455) | 4154003..4156288 | + | 2286 | WP_010989300.1 | hypothetical protein | - |
| O1A30_RS20460 (O1A30_20460) | 4156592..4156843 | + | 252 | WP_024131240.1 | hypothetical protein | - |
| O1A30_RS20465 (O1A30_20465) | 4156925..4157377 | + | 453 | WP_000434168.1 | hypothetical protein | - |
| O1A30_RS20470 (O1A30_20470) | 4157557..4158045 | - | 489 | WP_000622308.1 | GNAT family N-acetyltransferase | Toxin |
| O1A30_RS20475 (O1A30_20475) | 4158042..4158335 | - | 294 | WP_001143724.1 | DUF1778 domain-containing protein | Antitoxin |
| O1A30_RS20480 (O1A30_20480) | 4158762..4159775 | - | 1014 | WP_000449622.1 | site-specific integrase | - |
| O1A30_RS20485 (O1A30_20485) | 4159939..4161528 | - | 1590 | WP_000488995.1 | TraI domain-containing protein | - |
| O1A30_RS20490 (O1A30_20490) | 4161512..4163023 | - | 1512 | WP_001120833.1 | UvrD-helicase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 | 4145433..4278242 | 132809 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 17538.36 Da Isoelectric Point: 7.3252
>T273175 WP_000622308.1 NZ_CP118537:c4158045-4157557 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
Download Length: 489 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10906.59 Da Isoelectric Point: 6.3493
>AT273175 WP_001143724.1 NZ_CP118537:c4158335-4158042 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716G941 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716D9M3 |