Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4040530..4041046 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag O1A30_RS19850 Protein ID WP_000220578.1
Coordinates 4040530..4040814 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag O1A30_RS19855 Protein ID WP_000212724.1
Coordinates 4040804..4041046 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS19835 (O1A30_19835) 4035742..4037394 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
O1A30_RS19840 (O1A30_19840) 4037803..4039941 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
O1A30_RS19845 (O1A30_19845) 4040062..4040526 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O1A30_RS19850 (O1A30_19850) 4040530..4040814 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O1A30_RS19855 (O1A30_19855) 4040804..4041046 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O1A30_RS19860 (O1A30_19860) 4041124..4043037 - 1914 WP_001212152.1 BglG family transcription antiterminator -
O1A30_RS19865 (O1A30_19865) 4043054..4043794 - 741 WP_000779260.1 KDGP aldolase family protein -
O1A30_RS19870 (O1A30_19870) 4043791..4044909 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
O1A30_RS19875 (O1A30_19875) 4044893..4046026 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T273174 WP_000220578.1 NZ_CP118537:c4040814-4040530 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT273174 WP_000212724.1 NZ_CP118537:c4041046-4040804 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References