Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3938008..3938584 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag O1A30_RS19385 Protein ID WP_001131963.1
Coordinates 3938297..3938584 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag O1A30_RS19380 Protein ID WP_000063142.1
Coordinates 3938008..3938310 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS19365 (O1A30_19365) 3934518..3936668 + 2151 WP_000379910.1 pyruvate/proton symporter BtsT -
O1A30_RS19370 (O1A30_19370) 3936763..3936966 + 204 WP_000460616.1 YbdD/YjiX family protein -
O1A30_RS19375 (O1A30_19375) 3936977..3937933 + 957 WP_000187846.1 GTPase -
O1A30_RS19380 (O1A30_19380) 3938008..3938310 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
O1A30_RS19385 (O1A30_19385) 3938297..3938584 - 288 WP_001131963.1 BrnT family toxin Toxin
O1A30_RS19390 (O1A30_19390) 3938837..3939751 - 915 WP_000290515.1 restriction endonuclease -
O1A30_RS19395 (O1A30_19395) 3939949..3943458 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T273173 WP_001131963.1 NZ_CP118537:c3938584-3938297 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT273173 WP_000063142.1 NZ_CP118537:c3938310-3938008 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References