Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1417851..1418471 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag O1A30_RS06925 Protein ID WP_001280991.1
Coordinates 1417851..1418069 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag O1A30_RS06930 Protein ID WP_000344807.1
Coordinates 1418097..1418471 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS06885 (O1A30_06885) 1413074..1413643 + 570 WP_000779802.1 YbaY family lipoprotein -
O1A30_RS06890 (O1A30_06890) 1413676..1414065 - 390 WP_000961285.1 MGMT family protein -
O1A30_RS06900 (O1A30_06900) 1414296..1415846 - 1551 WP_000213129.1 EAL domain-containing protein -
O1A30_RS06905 (O1A30_06905) 1416071..1416331 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
O1A30_RS06910 (O1A30_06910) 1416337..1416477 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
O1A30_RS06915 (O1A30_06915) 1416533..1417003 - 471 WP_000136183.1 YlaC family protein -
O1A30_RS06920 (O1A30_06920) 1417121..1417672 - 552 WP_001278793.1 maltose O-acetyltransferase -
O1A30_RS06925 (O1A30_06925) 1417851..1418069 - 219 WP_001280991.1 HHA domain-containing protein Toxin
O1A30_RS06930 (O1A30_06930) 1418097..1418471 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
O1A30_RS06935 (O1A30_06935) 1418967..1422116 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
O1A30_RS06940 (O1A30_06940) 1422139..1423332 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T273168 WP_001280991.1 NZ_CP118537:c1418069-1417851 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT273168 WP_000344807.1 NZ_CP118537:c1418471-1418097 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References