Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849642..850267 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O1A30_RS04180 Protein ID WP_000911334.1
Coordinates 849869..850267 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag O1A30_RS04175 Protein ID WP_000557549.1
Coordinates 849642..849869 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS04145 (O1A30_04145) 845191..845676 + 486 WP_000082606.1 hypothetical protein -
O1A30_RS04150 (O1A30_04150) 845679..845876 + 198 WP_001240756.1 hypothetical protein -
O1A30_RS04155 (O1A30_04155) 845999..846490 + 492 WP_044790498.1 hypothetical protein -
O1A30_RS04160 (O1A30_04160) 846572..847561 + 990 WP_274844510.1 hypothetical protein -
O1A30_RS04165 (O1A30_04165) 848133..848939 - 807 WP_077905073.1 DUF1460 domain-containing protein -
O1A30_RS04170 (O1A30_04170) 849214..849465 - 252 WP_001540858.1 hypothetical protein -
O1A30_RS04175 (O1A30_04175) 849642..849869 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
O1A30_RS04180 (O1A30_04180) 849869..850267 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
O1A30_RS04185 (O1A30_04185) 851074..851610 + 537 WP_001038500.1 STM3031 family outer membrane protein -
O1A30_RS04190 (O1A30_04190) 851657..852289 + 633 WP_000835268.1 YfdX family protein -
O1A30_RS04195 (O1A30_04195) 853008..853589 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 843247..858712 15465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T273166 WP_000911334.1 NZ_CP118537:849869-850267 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT273166 WP_000557549.1 NZ_CP118537:849642-849869 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References