Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 231140..231900 Replicon chromosome
Accession NZ_CP118537
Organism Salmonella enterica subsp. enterica serovar Typhi strain S3

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag O1A30_RS01130 Protein ID WP_000533908.1
Coordinates 231415..231900 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag O1A30_RS01125 Protein ID WP_000965889.1
Coordinates 231140..231427 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1A30_RS01105 (O1A30_01105) 226545..227456 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
O1A30_RS01110 (O1A30_01110) 227466..229535 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
O1A30_RS01115 (O1A30_01115) 229925..230353 + 429 Protein_221 IS3 family transposase -
O1A30_RS01120 (O1A30_01120) 230495..230962 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
O1A30_RS01125 (O1A30_01125) 231140..231427 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
O1A30_RS01130 (O1A30_01130) 231415..231900 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
O1A30_RS01135 (O1A30_01135) 232271..232810 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
O1A30_RS01140 (O1A30_01140) 232986..233198 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
O1A30_RS01145 (O1A30_01145) 233489..233776 - 288 Protein_227 HTH-type transcriptional regulator -
O1A30_RS01150 (O1A30_01150) 234215..234925 + 711 WP_000190524.1 DUF3053 domain-containing protein -
O1A30_RS01155 (O1A30_01155) 234975..235949 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
O1A30_RS01160 (O1A30_01160) 236168..236830 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T273164 WP_000533908.1 NZ_CP118537:231415-231900 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT273164 WP_000965889.1 NZ_CP118537:231140-231427 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References