Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4231803..4232584 Replicon chromosome
Accession NZ_CP118536
Organism Salmonella enterica subsp. enterica serovar Typhi strain S7

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PWA19_RS20950 Protein ID WP_000626103.1
Coordinates 4231803..4232294 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PWA19_RS20955 Protein ID WP_001110456.1
Coordinates 4232291..4232584 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA19_RS20925 (PWA19_20925) 4227570..4228934 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PWA19_RS20930 (PWA19_20930) 4228931..4229965 - 1035 WP_001195363.1 ParA family protein -
PWA19_RS20935 (PWA19_20935) 4230179..4230253 - 75 Protein_4097 helix-turn-helix domain-containing protein -
PWA19_RS20940 (PWA19_20940) 4230633..4230710 + 78 Protein_4098 porin family protein -
PWA19_RS20945 (PWA19_20945) 4230810..4231562 + 753 WP_001785756.1 non-specific acid phosphatase -
PWA19_RS20950 (PWA19_20950) 4231803..4232294 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PWA19_RS20955 (PWA19_20955) 4232291..4232584 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PWA19_RS20960 (PWA19_20960) 4232901..4233123 + 223 Protein_4102 hypothetical protein -
PWA19_RS20965 (PWA19_20965) 4233389..4234264 + 876 WP_000921674.1 AraC family transcriptional regulator -
PWA19_RS20970 (PWA19_20970) 4234261..4234548 + 288 WP_001269916.1 transcriptional regulator RtsB -
PWA19_RS20975 (PWA19_20975) 4234571..4234787 + 217 Protein_4105 hypothetical protein -
PWA19_RS20980 (PWA19_20980) 4234795..4235139 + 345 WP_100680417.1 Ig-like domain-containing protein -
PWA19_RS20985 (PWA19_20985) 4235426..4236331 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T273161 WP_000626103.1 NZ_CP118536:c4232294-4231803 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT273161 WP_001110456.1 NZ_CP118536:c4232584-4232291 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References