Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3992282..3992798 Replicon chromosome
Accession NZ_CP118536
Organism Salmonella enterica subsp. enterica serovar Typhi strain S7

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PWA19_RS19625 Protein ID WP_000220578.1
Coordinates 3992282..3992566 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PWA19_RS19630 Protein ID WP_000212724.1
Coordinates 3992556..3992798 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA19_RS19610 (PWA19_19610) 3987494..3989146 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
PWA19_RS19615 (PWA19_19615) 3989555..3991693 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
PWA19_RS19620 (PWA19_19620) 3991814..3992278 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PWA19_RS19625 (PWA19_19625) 3992282..3992566 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWA19_RS19630 (PWA19_19630) 3992556..3992798 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PWA19_RS19635 (PWA19_19635) 3992876..3994789 - 1914 WP_001212152.1 BglG family transcription antiterminator -
PWA19_RS19640 (PWA19_19640) 3994806..3995546 - 741 WP_000779260.1 KDGP aldolase family protein -
PWA19_RS19645 (PWA19_19645) 3995543..3996661 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PWA19_RS19650 (PWA19_19650) 3996645..3997778 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T273159 WP_000220578.1 NZ_CP118536:c3992566-3992282 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT273159 WP_000212724.1 NZ_CP118536:c3992798-3992556 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References