Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3889672..3890248 Replicon chromosome
Accession NZ_CP118536
Organism Salmonella enterica subsp. enterica serovar Typhi strain S7

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PWA19_RS19160 Protein ID WP_001131963.1
Coordinates 3889961..3890248 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PWA19_RS19155 Protein ID WP_000063142.1
Coordinates 3889672..3889974 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA19_RS19140 (PWA19_19140) 3886182..3888332 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PWA19_RS19145 (PWA19_19145) 3888427..3888630 + 204 WP_000460616.1 YbdD/YjiX family protein -
PWA19_RS19150 (PWA19_19150) 3888641..3889597 + 957 WP_000187846.1 GTPase -
PWA19_RS19155 (PWA19_19155) 3889672..3889974 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PWA19_RS19160 (PWA19_19160) 3889961..3890248 - 288 WP_001131963.1 BrnT family toxin Toxin
PWA19_RS19165 (PWA19_19165) 3890501..3891415 - 915 WP_000290515.1 restriction endonuclease -
PWA19_RS19170 (PWA19_19170) 3891613..3895122 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T273158 WP_001131963.1 NZ_CP118536:c3890248-3889961 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT273158 WP_000063142.1 NZ_CP118536:c3889974-3889672 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References